The multifunctional RNA-binding protein La is often aberrant expressed in tumor tissue and supports tumor-promoting cellular processes such as proliferation and invasion of cancerous cells. Recent findings suggest that this RNA-binding protein contributes to tumorigenesis. It is likely that human La promotes such tumor-promoting processes by stimulating the expression of cellular proteins implicated in tumorigenesis. In this review we summarize the current knowledge about the implication of the RNA-binding protein La in tumorigenesis.